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TECHNOLOGY

ATEMs has expertise in the field of tissue engineering

TECHNOLOGY

ATEMs has expertise in the field of
tissue engineering

AMC (ATEMs Medicinal Cell)

Immature cartilage tissue-derived cell

AMC is a cartilage cell separated from immature cartilage tissue, As a cell source with a similar level of
safety to autologous cells or adult stem cells, it has superior proliferative and differentiation capacity than adult stem cells.
It is a new cell source for tissue regeneration therapy that can be applied to various technologies and product development.

Characteristics of
cell-derived tissue regeneration

Degeneration due to aging or physical trauma causes damages to the tissue, which makes it impossible to function as a normal tissue.

In the case of tissue damage in adults, stem cells are secreted and do not regenerate similarly to normal tissues, leaving wounds or scars.

In case of AMC, young stem cells are secreted, enabling tissue regeneration without wounds or scars.

By using these AMCs, ATEMs enables tissue regeneration without wounds or scars in the damaged area like normal tissue.

AMC’s Competitiveness

Adult stem cells’ effects and characteristics are not the same because they are supplied with cells from several donors.
However, AMC is capable of obtaining a large amount of cells with the same effect and characteristics from a single donor.

Adult stem cells have a limited number of usable cells that can be obtained, but AMCs can produce large numbers of usable cells.

Value of AMC’s therapeutics development

It has the same potential as embryonic stem cells and is as safe as adult stem cells.

With high potential and safety, it has high access to permits

Comparison of characteristics between AMC and various stem cells

AMC is a cell that can secure large quantities based on its excellent proliferation and differentiation ability.

AMC is a suitable cell for the treatment of patients with tissue degeneration and defects
because there is no immune rejection and no cell carcinogenicity or reproductive toxicity.

It is a cell with safety such as acute and chronic toxicity, immunological toxicity, genetic toxicity, and tumorigenicity.

AMC is a cell that has the advantages of both adult stem cells and embryonic stem cells.

Patents

Patent Number: (10-15368150000) : Medicinal composition for the prevention and treatment of
immune diseases using fetal cartilage-derived cells

Patent Number: (10-15836660000): Medicinal composition for the prevention and treatment of
autoimmune diseases or transplant rejection diseases using fetal cartilage-derived cells.

Paper

In vivo bioreactor using cellulose membrane benefit engineering cartilage by improving the
chondrogenesis and modulating the immune response. Tissue Engineering and Regenerative Medicine. 2020

Engineered Cartilage Utilizing Fetal Cartilage-Derived Progenitor Cells for Cartilage Repair.
scientific report. 2020

Immunophenotype and Immune-Modulatory Activities of Human Fetal Cartilage-Derived Progenitor Cells.
Cell Transplant. 2019

Characterization of Human Fetal Cartilage Progenitor Cells During Long-Term Expansion in a Xeno-Free Medium.
Tissue Engineering and Regenerative Medicine. 2018

Comparison of fetal cartilage-derived progenitor cells isolated at different developmental stages in a rat model.
Dev Growth Differ. 2016

Fetal Cartilage-derived Cells have Stem Cell Properties and are a Highly Potent Cell Source for Cartilage Regeneration.
Cell Transplant. 2015

AMC (ATEMs Medicinal Cell)

Immature cartilage tissue-derived cell

AMC is a cartilage cell separated from immature cartilage tissue,
As a cell source with a similar level of safety to autologous cells or adult
stem cells, it has superior proliferative and differentiation capacity than
adult stem cells. It is a new cell source for tissue regeneration therapy
that can be applied to various technologies and product development.

Characteristics of
cell-derived tissue regeneration

Degeneration due to aging or physical trauma causes damages to the
tissue, which makes it impossible to function as a normal tissue.

In the case of tissue damage in adults, stem cells are secreted and
do not regenerate similarly to normal tissues, leaving wounds or scars.

In case of AMC, young stem cells are secreted, enabling tissue
regeneration without wounds or scars.

By using these AMCs, ATEMs enables tissue regeneration without
wounds or scars in the damaged area like normal tissue.

AMC’s Competitiveness

Adult stem cells’ effects and characteristics are not the same because
they are supplied with cells from several donors.
However, AMC is capable of obtaining a large amount of cells with the
same effect and characteristics from a single donor.

Adult stem cells have a limited number of usable cells that can be
obtained, but AMCs can produce large numbers of usable cells.

Value of AMC’s therapeutics development

It has the same potential as embryonic stem cells and is as safe as
adult stem cells.

With high potential and safety, it has high access to permits

Comparison of characteristics between
AMC and various stem cells

AMC is a cell that can secure large quantities based on its excellent
proliferation and differentiation ability.

AMC is a suitable cell for the treatment of patients with tissue
degeneration and defects

because there is no immune rejection and no cell carcinogenicity or
reproductive toxicity.

It is a cell with safety such as acute and chronic toxicity, immunological
toxicity, genetic toxicity, and tumorigenicity.

AMC is a cell that has the advantages of both adult stem cells and
embryonic stem cells.

Patents

Patent Number: (10-15368150000) : Medicinal
composition for the prevention and treatment of
immune diseases using fetal cartilage-derived cells

Patent Number: (10-15836660000): Medicinal
composition for the prevention and treatment of
autoimmune diseases or transplant rejection diseases
using fetal cartilage-derived cells.

Paper

In vivo bioreactor using cellulose membrane benefit
engineering cartilage by improving the
chondrogenesis and modulating the immune response.
Tissue Engineering and Regenerative Medicine. 2020

Engineered Cartilage Utilizing Fetal Cartilage-Derived
Progenitor Cells for Cartilage Repair.
scientific report. 2020

Immunophenotype and Immune-Modulatory Activities
of Human Fetal Cartilage-Derived Progenitor Cells.
Cell Transplant. 2019

Characterization of Human Fetal Cartilage
Progenitor Cells During Long-Term
Expansion in a Xeno-Free Medium.
Tissue Engineering and Regenerative Medicine. 2018

Comparison of fetal cartilage-derived progenitor cells
isolated at different developmental stages in a rat model.
Dev Growth Differ. 2016

Fetal Cartilage-derived Cells have Stem Cell Properties
and are a Highly Potent Cell Source for Cartilage
Regeneration. Cell Transplant. 2015