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PIPELINE

Based on world-class tissue engineering R&D,
we develop regenerative medicine therapy that reconstructs cartilage tissue

PIPELINE

Based on world-class tissue engineering R&D,
we develop regenerative medicine therapy
that reconstructs cartilage tissue

A-Film-MAdhesion Prevention Film for Tendon & Ligament

Introduction of
Target Product

Tendon/ligament tissue with a lot of movement adheres to surrounding tissues (skin tissue, etc.) due to
surgical operation or post-traumatic inflammation, leaving external adhesion scars or causing exercise disorders.
It is a customized tendon/ligament anti-adhesion barrier to prevent such adhesion.

Strong Points of
Target Product

It is a biocompatible product developed with natural biomaterials (cartilage extracellular matrix) that
has both excellent function of physical barrier function and anti-vascular.

Very thin and high tensile strength can maintain a physical stability without interfering with the motility of
tissues in areas with high movement.

By developing the product's decomposition period according to the healing period of the tendon/ligament tissue,
the target product was designed to maintain the anti-adhesion effect only in maintaining the proper anti-adhesion
effect during the healing period

Adhesion between tissues strengthens the function of the anti-adhesion barrier through a physical barrier developed
with cartilage-derived extracellular matrix components that inhibit inflammation and angiogenesis.

Patent

Patent Application Number: 10-1772316 Composition for anti-adhesion

Tendon / ligament

Introduction of
tendon / ligament
adhesion mechanism

When the tissue is injured by internal/external factors, the deposition of fibrin occurs during the healing process.
If the fibrous tissue at the deposit site is not decomposed and exists in the adjacent tissue, it induces the
proliferation of fibrous cells and the influx of new blood vessels, which develops into adhesion with the adjacent tissue.

The adhesion mechanism differs depending on the human organ/tissue, and unlike the abdominal cavity or
intrathoracic organ, in the case of adhesions that occur after surgery such as ligaments or joints, long-term
anti-adhesion treatments are required because continuous wounds may occur during rehabilitation for 2-3 months.

Needs for
anti-adhesion barrier

A physical barrier process is required to prevent adhesions to the injured tissue and adjacent organs.

Since the mechanism of adhesion and the recovery rate are different depending on the organ, an anti-adhesion
agent considering the characteristics of each organ is required.

Anti-adhesion drugs in the form of drugs may interfere with wound healing and have limitations in that it is difficult to
maintain long-term efficacy and difficult to apply to local areas.

In the case of solutions or gels, application is limited due to the difficulty of precise application of the site of application and
too rapid decomposition.

A-Film-M
Adhesion Prevention Film for Tendon & Ligament

Introduction of
Target Product

Tendon/ligament tissue with a lot of movement
adheres to surrounding tissues (skin tissue,
etc.) due to surgical operation or post-traumatic
inflammation, leaving external adhesion scars
or causing exercise disorders.
It is a customized tendon/ligament anti-adhesion
barrier to prevent such adhesion.

Strong Points of
Target Product

It is a biocompatible product developed with
natural biomaterials (cartilage extracellular
matrix) that has both excellent function of
physical barrier function and anti-vascular.

Very thin and high tensile strength can
maintain a physical stability without interfering
with the motility of tissues in areas with high
movement.

By developing the product's decomposition
period according to the healing period of the
tendon/ligament tissue, the target product was
designed to maintain the anti-adhesion effect
only in maintaining the proper anti-adhesion
effect during the healing period

Adhesion between tissues strengthens the
function of the anti-adhesion barrier through
a physical barrier developed with cartilage -
derived extracellular matrix components that
inhibit inflammation and angiogenesis.

Patent

Patent Application Number: 10-1772316
Composition for anti-adhesion

Tendon / ligament

Introduction of
tendon / ligament
adhesion
mechanism

When the tissue is injured by internal/external
factors, the deposition of fibrin occurs during
the healing process. If the fibrous tissue at the
deposit site is not decomposed and exists in
the adjacent tissue, it induces the proliferation
of fibrous cells and the influx of new blood
vessels, which develops into adhesion with
the adjacent tissue.

The adhesion mechanism differs depending
on the human organ/tissue, and unlike the
abdominal cavity or intrathoracic organ, in the
case of adhesions that occur after surgery
such as ligaments or joints, long-term
anti-adhesion treatments are required because
continuous wounds may occur during
rehabilitation for 2-3 months.

Needs for
anti-adhesion
barrier

A physical barrier process is required to
prevent adhesions to the injured tissue and
adjacent organs.

Since the mechanism of adhesion and the
recovery rate are different depending on the
organ, an anti-adhesion agent considering the
characteristics of each organ is required.

Anti-adhesion drugs in the form of drugs may
interfere with wound healing and
have limitations in that it is difficult to maintain
long-term efficacy and difficult to apply to
local areas.

In the case of solutions or gels, application
is limited due to the difficulty of precise
application of the site of application and too
rapid decomposition.